LIPOSOMAL Nicotinamide Riboside (NR)
Nicotinamide Riboside (NR) is a form of vitamin B3 and a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme involved in cellular energy production, DNA repair, and metabolic processes. It is naturally found in small amounts in foods like milk, yeast, and green vegetables, but is commonly taken as a supplement to boost NAD+ levels, potentially supporting healthy ageing, energy metabolism, and cognitive function. Liposomal NR involves encapsulating NR within liposomes—tiny, spherical vesicles made from phospholipids that resemble cell membranes. This encapsulation protects NR from degradation in the digestive tract, enhances its solubility, and improves absorption by allowing the liposomes to fuse with cell membranes for direct delivery into cells and tissues, including crossing barriers like the blood-brain barrier more effectively than traditional forms.
10 Overview Benefits of Liposomal Nicotinamide Riboside (NR) Over Traditional Powder, Capsules, and Tablets
Here are 10 key benefits of liposomal NR compared to traditional forms, focusing on its enhanced delivery system that addresses issues like poor absorption, degradation, and limited tissue penetration:
1. Superior Bioavailability: Liposomal encapsulation significantly increases absorption into the bloodstream, leading to higher plasma concentrations (e.g., 2.76-fold higher C_max and 5.32-fold higher AUC) compared to non-liposomal NR.
2. Enhanced Stability and Protection: The liposomal layer shields NR from breakdown in the gut and aqueous environments, preventing degradation that occurs with traditional forms during digestion.
3. Improved Brain Distribution: Achieves greater penetration across the blood-brain barrier, resulting in higher brain concentrations (e.g., 2.93-fold higher C_max) for better neurological support.
4. Faster Absorption and Onset: Provides rapid uptake without extensive breakdown in the GI tract, leading to quicker elevation of NAD+ levels than slower-absorbing traditional supplements.
5. Greater NAD+ Boosting Efficiency: More effectively raises tissue NAD+ and ATP levels, enhancing cellular energy and repair processes over conventional NR.
6. Enhanced Neuroprotective Effects: In models of cerebral ischemia, it reduces infarct volume by an additional 35.4%, promotes neuronal survival, and attenuates glial activation more than traditional NR.
7. Better Cellular and Targeted Delivery: Liposomes mimic natural vesicles, enabling direct fusion with cell membranes for efficient intracellular release, surpassing the limitations of standard forms.
8. Potential for Lower Doses: Achieves comparable or superior NAD+ elevation and health benefits with smaller amounts due to improved utilization, reducing the need for high doses in traditional supplements.
9. Improved Behavioral and Functional Outcomes: Demonstrates significant enhancements in recovery, such as in stroke models, where it outperforms traditional NR in promoting overall neurorestoration.
10. Gentler on the Digestive System: Minimizes gastrointestinal breakdown and potential side effects, making it more tolerable and effcient for long-term use compared to non-encapsulated powders or tablets.