LIPOSOMAL Methylene blue
Methylene blue is a synthetic compound first synthesised in 1876 as a dye for textiles like cotton, wool, and silk. It became the first fully synthetic drug used in medicine, initially for treating malaria. Over time, it has been employed as a stain in microbiology, an oxidation-reduction indicator in chemistry, and in various medical applications
It exhibits properties such as antioxidant, neuroprotective, antimicrobial, and antidepressant effects, though many are based on preliminary research and require further study. Methylene blue is typically administered intravenously by healthcare professionals, but oral and topical forms exist for specific uses.
Here are the top 10 potential benefits of methylene blue, compiled from medical reviews and studies. Many are established for specific uses, while others are emerging based on preclinical or small-scale human research.
1. Treatment of Methemoglobinemia: Approved by the FDA to restore oxygen-carrying capacity in red blood cells by converting ferric iron back to ferrous iron, addressing this blood disorder caused by certain drugs, chemicals, or genetics.
2. Neuroprotective Effects: Protects neurons from oxidative stress and inflammation; it may help in conditions like Alzheimer’s, Parkinson’s, and Huntington’s by reducing amyloid plaques, promoting tau protein clearance, and enhancing mitochondrial function in the brain.
3. Antioxidant Properties: Acts as an electron carrier in mitochondria to reduce superoxide production and neutralise free radicals, helping manage cellular stress and potentially enhancing overall cellular protection via pathways like Nrf2 expression.
4. Cognitive and Memory Enhancement: Improves memory retrieval, spatial memory, and brain activity in areas linked to attention; studies show bene ts in healthy individuals and models of neurodegenerative diseases.
5. Antidepressant Effects: Shares structural similarities with tricyclic antidepressants and has shown potential in treating severe depressive illness, possibly by modulating neurotransmitter pathways.
6. Antimalarial Activity: Effectively treats Plasmodium falciparum infections, especially in resistant strains, and was historically the first synthetic antimalarial drug.
7. Prevention of Ifosfamide-Induced Encephalopathy: Used off - label to prevent or treat brain toxicity from ifosfamide chemotherapy, inhibiting neurotoxic metabolites and resolving symptoms like confusion and seizures in many cases.
8. Management of Vasoplegic Syndrome: Helps stabilise blood pressure in post-surgical vasodilative shock by inhibiting nitric oxide effects, often used when other treatments like epinephrine are ineffective.
9. Antimicrobial Properties: Exhibits effects against bacteria, fungi, viruses, and parasites through DNA damage; historically used for infections like gonorrhoea, Candida, Lyme disease, and studied for COVID-19.
10. Anti-Aging Benefits: Counters mitochondrial dysfunction and oxidative stress, potentially reducing skin wrinkles, improving elasticity, slowing age-related memory
Bioavailability
Food -Negligible (not naturally present in significant amounts in food sources; it is primarily a synthetic compound used as a dye in some food testing applications).
Supplements, capsules, tablets, liquid and powder form 0.53% which is quite high), with good oral absorption from capsules or tablets, peaking in plasma after 30-60 minutes.
Liposomal delivery system as used by Spawn Nutra Enhanced, with liposomal formulations improving delivery, stability, and tissue targeting, offering better bioavailability and mitochondrial concentration compared to standard oral treatment . We have an uptake of 97% nearly !!!!!