LIPOSOMAL Nicotinamide Mononucleotide (NMN)
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound and a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme involved in cellular energy production, DNA repair, metabolic regulation, and healthy aging. It is found in trace amounts in foods like broccoli, edamame, and avocados, but is commonly supplemented to counteract the age-related decline in NAD+ levels, which can contribute to fatigue, cognitive decline, and metabolic issues. Liposomal NMN encapsulates the molecule within liposomes—nano-sized, spherical vesicles made of phospholipids that mimic the structure of cell membranes. This delivery system protects NMN from degradation by stomach acids, digestive enzymes, and harsh gastrointestinal conditions, while facilitating direct fusion with cell membranes for enhanced absorption, bioavailability, and targeted delivery to tissues, including the brain and muscles. By mimicking the body’s natural extracellular vesicles, liposomal NMN overcomes the limitations of NMN’s hydrophilic nature, such as poor solubility and low oral uptake in traditional forms.
10 Overview Benefits of Liposomal Nicotinamide Mononucleotide (NMN) Over Traditional Powder, Capsules, and Tablets. Here are 10 key benefits of liposomal NMN compared to traditional forms, emphasising its advanced delivery mechanism that addresses challenges like degradation, low absorption, and inefficient cellular uptake:
1. Superior Bioavailability: Achieves significantly higher bioavailability, with absorption rates up to 3-5 times greater, allowing more NMN to reach the bloodstream and convert to NAD+ effectively.
2. Enhanced Absorption: The liposomal encapsulation protects NMN from gastrointestinal degradation, enabling direct delivery and bypassing enzymatic barriers that limit traditional forms.
3. Improved Stability: Shields NMN from harsh digestive environments, acids, and enzymes, maintaining its integrity longer than unprotected traditional supplements.
4. Direct Cellular Delivery: Liposomes fuse with cell membranes for targeted intracellular release, mimicking natural transport systems and outperforming the passive absorption of standard NMN.
5. Greater NAD+ Elevation: Leads to more substantial increases in blood NAD+ levels (e.g., 84% in studies), providing superior support for energy production and anti-aging compared to non-liposomal NMN.
6. Faster Onset of Effects: Delivers quicker systemic circulation and cellular uptake, resulting in more rapid benefits like improved energy and metabolism over the slower action of traditional forms.
7. Potential for Lower Doses: Achieves equivalent or better results with smaller amounts (e.g., 100-300 mg vs. 250-1,000 mg), reducing the need for high doses that may be less efficient in standard supplements.
8. Better Tissue and Brain Penetration: Enhances delivery across barriers like the blood-brain barrier, supporting cognitive health and tissue-specific NAD+ boosts more effectively than traditional NMN.
9. Reduced Gastrointestinal Side Effects: Minimises issues like nausea or diarrhoea by protecting the compound and requiring lower doses, making it gentler on the digestive system.
10. Amplified Health Outcomes: Provides more pronounced benefits in areas like DNA repair, mitochondrial function, cognition, physical performance, and longevity due to optimised delivery and efficacy.